Welcome to the BIDMC Mass Spectrometry and Proteomics Core


'Specializing in a targeted proteomics approach towards cellular signaling

ABOUT US: The mass spectrometry and proteomics core at Beth Israel Deaconess Medical Center was established in 2004 and continues to grow rapidly. We provide excellent proteomics services with low prices and fast turnaround times. We have cutting edge equipment operated at optimal sensitivity and work with world class researchers. We also mainatin a very active internal cancer proteomics research program with collaborative efforts. Our expertise is in identifying protein modifications and dynamic protein-protein interactions. We look forward to serving you and progressing your research to the next level.

The lab is hiring senior research personnel and post-doctoral researchers, click here for a job description.

Proteomics Services Provided

  • Protein Complex Identification
    (protein complexes, protein-protein interactions)
  • Identification of Post-Translational Modifications
    (phosphorylation, acetylation, ubiquitination, etc.)
  • Relative Quantification
    (Label-free quantification, SILAC, iTRAQ, TMT, ISIL)
    • Protein complex stoichiometry
    • Quantification of phosphorylation sites 
  • Molecular Weight Determination

 Instrumentation

  • Thermo Scientific LTQ Orbitrap XL-ETD
    (ultra high resolution and mass accuracy, HCD collision cell, ETD fragmentation for labile modifications)
  • Thermo Scientific LTQ 2D linear ion trap
    (very fast and very sensitive, great for protein ID)
  • Applied Biosystems/MDS Sciex 5500 QTRAP triple quadrupole
    (coming soon for targeted label-free quantitation and metabolomics)
  • Proxeon EasynLC (2)
    (nanoliter flow rates, very reproducible and robust)
  • Shimadzu Prominence UFLC
  • Michrom Bioresources Paradigm 2D-HPLC

    ThermoScientific LTQ Orbitrap XL-ETD

                  

    Proxeon EASY-nLC

     

       

 

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