Welcome to the BIDMC Mass Spectrometry Facility and John Asara Laboratory


'Specializing in a multi-omics proteomics, metabolomics & lipidomics approach'

People/Contact Us
Prior to submitting samples, please contact our lab director to discuss the project (special projects may be possible):

Lab Director and PI:

John M. Asara, Ph.D.
Associate Professor of Medicine
Harvard Medical School
Director, Mass Spectrometry Core
Beth Israel Deaconess Medical Center
Phone: 617-735-2651
Email:
jasara@bidmc.harvard.edu


John Asara Curriculum Vitae (CV)

Biography

Dr. Asara is an Associate Professor at Harvard Medical School and the Director of the Mass Spectrometry Facility at Beth Israel Deaconess Medical Center in Boston, MA. He received his Ph.D. in Analytical Chemistry from Michigan State University in 1999 and did postdoctoral work at Harvard University in proteomics before a short stint at a biotechnology company. He then established the mass spectrometry facility at BIDMC in 2004 with a single used instrument starting with proteomics analysis and has grown the core into a multi-omics facility capable of proteomics, phosphoproteomics, metabolomics, lipidomics, stable isotope labeling and flux analysis using state-of-the-art Orbitrap and hybrid triple quadrupole instrumentation. Dr. Asara has developed methods for label-free quantification of peptides and proteins, in-gel stable isotope labeling as well as cross-species analyses of immunoprecipitation tandem MS data for biomarker discovery. A decade ago, Dr. Asara sequenced collagen peptides from both 68 million year old Tyrannosaurus rex and 80 million year old Brachylophosaurus fossils that preserved soft tissues. He has also developed polarity switching targeted metabolomics methods and untargeted lipidomics platforms from any biological source including 13C/15N metabolic flux platforms. His current research involves a serial-omics approach by using a single tiny sample of tumor tissue, biological fluid or cell pellet and then performing proteomics, metabolomics and lipidomics and integrating those datasets into a biological model. Dr. Asara has co-authored over 200 peer reviewed manuscripts. 


View Research Profile Pages Here:
Harvard Catalyst, Dana-Farber/Harvard Cancer Center



Research & Core Staff:

Min Yuan, B.S.
Sr. Research Associate
Phone: 617-735-2652
Email: myuan@bidmc.harvard.edu




He Huang, Ph.D.
Postdoctoral Research Fellow
Phone:617-735-2653
Email: hhuang4@bidmc.harvard.edu




Susanne Breitkopf, Ph.D.
Postdoctoral Research Fellow / Sr. Research Associate
Alumn





Ying Xu, Ph.D.
Postdoctoral Research Fellow
Phone: 617-735-2105
Email: yxu1@bidmc.harvard.edu




Shailender Nagpal, M.S.
Bioinformatics Consultant
Email: shailendernagpal@hotmail.com 



Alumni

Timothy Li -
Robert Dorkin - MIT
Lisa Freimark - Harvard University
Xuemei Yang - Novartis
Susanne Breitkopf - Pfizer
Ying Xu - Genzyme


*First-time users: To set up an account with the core, please contact John Asara, jasara@bidmc.harvard.edu , 617-735-2651.


Current address for sample submissions:

Beth Israel Deaconess Medical Center
Attn: John Asara/Mass Spectrometry Core
Center for Life Sciences
3 Blackfan Circle
Room 425
Boston, MA 02115




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