Recent Internal Research Poster/Oral Presentations:
Super-Omics: Liquid-Liquid Extractions from a single biopsy sample for metabolomics, phosphoproteomics and lipidomics........
A "Triomics" publication showing how global phosphoproteomics, global lipidomics and targeted metabolomics leads to a biological model in multiple myeloma
Cross-Omics: Correlating SILAC phosphoproteomics with polar metabolomics in BCR-ABL myeloma cells reveals a link between kinase inhibition and RNA processing
13C/15N Labeling of Polar Metabolites - In vivo and In vitro
Comparison of Label-Free quantitative technologies: MaxQuant (MS) vs. Skyline (MS) vs. Spectral Counting (MS/MS) vs. Average TIC (MS/MS) vs. Top3 TIC (MS/MS)
Proteomics/Metabolomics of Cancer Signaling:
Study: Cross-Species Proteomics Analyses Discovers a Novel Binding between P85-SHP2 in Cancer Cells
Recent Study: Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP) - tandem mass spectrometry (MS/MS) based proteomics
Study: Phosphoproteomics Protocol published in "The Red Book"
Study: Using tandem mass spectrometry to choose appropriate kinase inhibitor drugs in cancers: A personalized medicine strategy based on protein-protein interactions
Study/Protocol: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cell lines, fluids and tissues in Nature Protocols
Study: Metabolomics from Formalin Fixed Paraffin Embedded (FFPE) Tumor Tissue
Study: A simple method for quantifying proteins between experimental conditions based on MS/MS TIC
Study: A label-free method for quantification of protein phosphorylation sites based on MS/MS TIC values from targeted runs
Study: Detection of a phosphohistidine residue by LC/MS/MS using HCD that is critical to an alternative glycolytic pathway
A new article was just published in Metabolomics on our new polarity switching lipidomics platform with a complete protocol for sample prep and data analysis
Proteomics on Dinosaurs or "Fossilomics":
Study #1: Protein from a 68 million year old T. rex fossil sequenced at BIDMC Mass Spec Core
-Featured in the New York Times, Washington Post, Boston Globe, Newsweek, Discover Magazine, MSNBC, etc.
Study #2: Amino acid sequence from collagen used to perform rigorous phylogenetics analysis on T. rex and mastodon fossils
Study #3: Collagen from an 80 million year old Hadrosaur Brachylophosaurus canadensis sequenced by Orbitrap mass spectrometry
Publications Coming soon:
For latest manuscripts, click below (will be updated soon):